The PPARβδAgonist GW0742 Relaxes Pulmonary Vessels

gw0742  GW0742 is a synthetic, potent and selective PPAR-βδ agonist PPARs are ligand-dependent transcription factors which are involved in many physiological GW0742 docking conformation compared to the GW0742 of the crystal structure 3D detail of the amino acids forming polar bindings with GW0742

GW0742 Induces Early Neuronal Maturation of Cortical Post-Mitotic Neurons: Role of PPARβδ in Neuronal Maturation J Cell Physiol 2015, 23,597–606 GW0742 is a potent PPARβ and PPARδ agonist, with an IC50 of 1 nM for human PPARδ in binding assay, and EC50s of 1 nM, μM and 2 μM for human PPARδ,

GW0742 improved the decreased GIR in a dose-related manner, and this result verified that GW0742 improves IR in vivo Moreover, insulin GW0742 is a PPARδβ agonist that has been investigated for drug use by GlaxoSmithKline GW0742 Clinical data ATC code None Legal status